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Brett Mueller

Dr. Brett H Mueller II

Board-certified and fellowship-trained ophthalmologist

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Dr. Brett Mueller II is a board-certified and fellowship-trained ophthalmologist who specializes in and has performed thousands of cataract and refractive eye surgeries. With advanced fellowship training in refractive surgery, he hones a comprehensive range of skill sets needed to diagnose, address, and treat the full spectrum of refractive surgery. He is a 6th generation Texan and is ecstatic to be back in his hometown of San Antonio and being able to provide his patients better clear, crisp vision with leading surgical and refractive techniques and technology to improve eyesight.

Dr. Mueller also is an innovator and researcher having received his PhD studying new treatment modalities in the field of Ophthalmology. He is quickly making a name for himself and has over 45 scientific articles, papers, and abstracts published at both national and international meetings. At NuVision, he has served as both a principal investigator and sub-investigator on numerous industry-sponsored and FDA clinical trials. Dr. Mueller’s passion has always been to improve the field of ophthalmology and refractive surgery, and he looks forward to continuing to advance his field for his patients for many years to come.

An Open Letter to My Patients

I remember distinctly the exact time when I knew that I wanted to be an ophthalmologist. It was June 2007, and I had just completed a ten-day medical mission trip to Guatemala, where we served over 2000 patients. These patients came to our clinic seeking something very foreign to them: medical care. I recall one elderly man, blinded by cataracts, who took the arduous journey of over eight hours from the Guatemalan hills, with his grandson holding his hand, guiding each step. Upon entering the patient room with the general surgeon, we had to apologize to this elderly man and his grandson, because there was no ophthalmologist at the facility, so we could not remove his cataracts. As the look of joyous hope turned to despairing sadness, the grandfather communicated through tear-filled eyes that all he wanted to do was to see the sunrise one last time, behold the beauty of nature, and look into the eyes of his grandson. As they left, I felt an overwhelming sense of compassion, as I would have given anything to have been able to help him that day.

This story resonates with me, because I see this elderly man in every single one of the patients that I treat on a daily basis. Whether it be people who come in that are not able to experience life to their fullest because of their cataracts, or blinded because of their near-sightedness or astigmatism. I love being able to offer solutions to YOU for these conditions, and see that look of joy come across your face when you discover that there is a cure, that you can live life with clear, crisp vision.

These moments are even more special to me when I get to provide them for my family. My mother just recently had laser cataract surgery, and can now see 20/15 at distance, and read her book without the need of reading glasses. She describes her vision as like how it was when she was 20 years old. My sister, who was blinded by her nearsightedness since she was 3 just recently had the Visian ICL procedure performed on her, and she can now see 20/10 without the aid of glasses or contacts and describes everything in her world being in HD. These stories happen all the time with my patients, and I feel very blessed and fortunate to be able to share these moments with you.

As a refractive cataract surgeon, I daily witness patients and family members frustrated by loss of eyesight due to cataracts, or the debilitation from needing to be dependent upon prosthetic eyewear. Such experiences always bring me back to my experiences in Guatemala, but now, instead of telling this grandfather and grandson that there is nothing we can do, I can now say, “There is something that I can do … I can help you.”

Best regards,

Dr. Brett H. Mueller II

Education & Experience

Dr. Brett H. Mueller II is a Board Certified, fellowship-trained refractive and cataract surgeon. He is a 6th generation Texan and a 4th generation native of San Antonio. After receiving his undergraduate degree from Texas A&M University, he then received his medical degree and Ph.D. from the University of North Texas Health Science Center.

Dr. Mueller’s scientific work and academic accomplishments enabled him to author numerous publications and book chapters, perform over 30 presentations at national and international meetings, and is a recipient of several grants (including an NIH grant).

He was then accepted to attend an ophthalmology residency at the University of Louisville, where he developed a reputation for being a leader amongst his colleagues, serving as chief resident, and a skilled surgeon. After finishing residency training, Dr. Mueller then completed a one year refractive, cataract, and anterior segment fellowship with nationally and internationally recognized vision correction pioneer, Dr. Greg Parkhurst. He now specializes in state of the art laser guided cataract surgery and advanced lens implants that reduce or eliminate the need for glasses post-operatively. He also specializes in the full spectrum of refractive surgery which includes: modern LASIK, SMILE, ICLs, Refractive Lens Exchange, PRK, and Cross-Linking.

Professional Affiliations

  • Board Certified by the American Board of Ophthalmology
  • Fellow of the American Academy of Ophthalmology
  • American Society of Cataract and Refractive Surgery
  • Refractive Surgery Alliance
  • American-European Congress of Ophthalmic Surgery
  • Adjunct Clinical Assistant Professor at the University of Incarnate Word School of Osteopathic Medicine
  • Adjunct Clinical Assistant Professor at the University of Incarnate Word School of Optometry
  • Adjunct Assistant Professor at the University of North Texas Health Science Center
American Board of Ophthalmology logo
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Honors & Distinctions

  • Author of multiple peer-reviewed studies
  • Sub-Investigator for multiple clinical trials
  • Performed the most phaco cataract surgeries in the history of the U of L residency program, which included placing numerous toric and multifocal lenses, performing laser-assisted cataract surgery, and dropless cataract surgery
  • As a resident, one of the first surgeons in the state of Kentucky to place several different Micro-Invasive Glaucoma Surgery (MIGS) devices
  • Helped establish one of the first academic affiliations with Johnson & Johnson, enabling residents to be PRK- and LASIK-certified upon completion of their residency programs
  • Adjunct Assistant Professor at the University of North Texas Health Science Center – Department of Pharmacology and Neuroscience
  • Vice President of Clinic Research and Clinical Advisory Board for Vital Streams, LLC
  • Consultant for Nanoscope Technologies
  • Surgical Mission Trip – Performed cataract surgeries in Guerrero, Mexico
  • Refugee Vision Screenings – Performed vision screenings for 500 refugees in Louisville
  • Preliminary Internal Medicine Steering Committee

Research & Academics

  • Adjunct Clinical Assistant Professor at the University of Incarnate Word School of Osteopathic Medicine
  • Adjunct Clinical Assistant Professor at the University of Incarnate Word School of Optometry
  • Adjunct Assistant Professor at the University of North Texas Health Science Center
    1. Principal Investigator: Post-Approval Study of the PanOptix Trifocal Lens in Patients Who Have Had Post Refractive Myopic Laser Vision Correction Surgery.
    2. Principal Investigator: Post-Approval Study of the Vivity EDOF Lens in Patients Who Have Had Post Refractive Hyperopic Laser Vision Correction Surgery.
    3. Sub-Investigator: FDA Clinical Trial Investigating the EVO Intraocular Collamer Lens (ICL)
    4. Sub-Investigator: Yukon Study, Post-Market Evaluation of Surgeon Feedback of TECNIS Toric II Intraocular Lens (IOL). NXGT-201-TTL2. 2020
    5. Sub-Investigator: Post-Approval Study of the TECNIS Symfony Toric Lenses. 2019.
    6. Sub-Investigator: A Phase 3, Multicenter, Double-Masked, Randomized, Vehicle-Controlled, Parallel-Group Study Evaluating the Safety and Efficacy of AGN-190584 in Participants with Presbyopia. 2018.
    7. Sub-Investigator: A Prospective Clinical Trial to Evaluate the Safety and Effectiveness of Model SC9 Posterior Chamber Silicone Intraocular Lens for Primary Implantation in the Capsular Bag of the Eye for Visual Correction of Aphakia Secondary to Removal of a Cataractous Lens in Adult Patients With or Without Presbyopia. The IOL is Intended to Improve Near and Intermediate Vision as Compared to a Legally Marketed IOL. 2018.
    8. Sub-Investigator: Prospective, Randomized Phase 3 Study Comparing Two Models of a Travoprost Intraocular Implant to Timolol Maleate Ophthalmic Solution, USP, 0.5%. San Antonio, Texas. 2018.
    9. Sub-Investigator: iStent Inject Trabecular Micro-Bypass System Continuation Post-Approval Study. San Antonio, Texas. 2019


Original & Peer-Reviewed Publications

Book Chapters

  • Park Y, Ellis D, Mueller B, Stankowska D, Yorio T. Principles of Ocular Pharmacology. Handb Exp Pharmacol. 2017;242:3-30. doi: 10.1007/164_2016_25. PubMed PMID: 27730396.
  • Brett H. Mueller II, Dorota L. Stankowska and Raghu R. Krishnamoorthy (2011). Neuroprotection in Glaucoma, Glaucoma – Basic and Clinical Concepts, Dr Shimon Rumelt (Ed.), ISBN: 978-953-307-591-4, InTech, DOI: 10.5772/18465. Available from:


Ophthalmology Podcasts

  • Mueller B, Zhu D, and Shamie N. Getting Comfortable with Advanced Presbyopia-Correcting Technologies. Presbyopia Unlocked. Eyetube, BMC Today. 4/29/2020
  • Saenz B and Mueller B. Eye Health and Surgical Outcomes, Treating Keratoconus, Specializing in Ocular Aesthetics. Eyetube, The MODPOD. Episode 11. 2/25/2020.

Oral Presentations

(selected from national or international meetings only)

  • Mueller BH, Saenz B, Abraham N, Cavazos C, Parkhurst G. Toric Implantable Collamer Lenses: Early United States Experience. ASCRS Annual Meeting, May 16-17, 2020.
  • Uncertainties in Fellowship and Beyond | Priyanka Sood, MD; Neel Desai, MD; Lorraine Provencher, MD; Joshua Frenkel, MD, MPH; Brett Mueller, D.O., Ph.D. Millenial Live, Louisville, KY, September 2019
  • Dibas A, Stankowska D, Mueller B, Hidehiro O, Yorio T. Neuroprotective Effects of Inhibitors of Acid-Sensing Ion Channels (ASIC) in Optic Nerve Crush Model in Rodents. ARVO Annual Meeting, Abstract Number 3405. Baltimore, MD. May 2017
  • Mueller BH, Park Y, Ma H, Yorio T. Sigma-1 Receptor Stimulation Protects Purified RGCs from Ischemic Insult through the Phosphorylation of Extracellular Signal Regulated Kinase 1/2. ARVO Annual Meeting, Abstract Number 3699. Seattle, WA. May 2013
  • Mueller BH, Dibas A, Park Y, Ma H, Oku H, Fukuhara M, Kurimoto T, Ikeda T, Clark AF, Yorio T. Prolonged NMDA Treatment Induces Neuroprotective Pathways in Primary Retinal Ganglion Cells through Phosphorylation of cAMP Response Element-Binding Protein (CREB). XX Biennial Meeting of the International Society for Eye Research (ISER). Abstract number A-412-0006-00719. Berlin, Germany. July 21-25, 2012

Research Poster Presentation


A 4th Generation San Antonio Native

Dr. Mueller is excited to be home in San Antonio, serving NuVision patients as a Board Certified, fellowship-trained refractive surgeon. In his spare time, he loves spending time with his wife and 3 kids, enjoying an active lifestyle that includes running, cycling and hiking.

Brett Mueller